Ask the Pharmacist: The Low-Down on Antidepressants
By Carrie Lee, Pharm.D.
St. John's Pharmacies

Depression is a common illness that affects nearly one in 10 people in the United States. It affects men, women, children and people of all ages, races, and income levels. An imbalance of brain chemicals called serotonin and norepinephrine is often the likely cause of depression.

Depression is very treatable. In fact, most people who receive therapy receive some benefit.

In addition to treating depression, antidepressants are used to treat anxiety, obsessive-compulsive disorder, pre-menstrual syndrome, chronic pain, sleep disorders and as a tobacco cessation aid.

Symptoms of Depression

• Persistent sadness or anxiety.
• Loss of interest or pleasure in usual activities.
• Change in appetite, sleep habits, or energy level.
• Feeling helpless, hopeless, worthless or overwhelmed.
• Difficulty thinking, concentrating, or making decisions.
• Thoughts of death or suicide.

Treatment for Depression

Medications called “antidepressants” are generally prescribed to treat depression. Talk therapy may also be recommended. Your doctor will determine the best treatment for you after reviewing your symptoms, physical examination, and history.

Antidepressant Medication Tips

1. Antidepressants are not addicting or habit-forming.
2. Antidepressant medications should be taken every day.
3. You should allow three to six weeks to see the full effect of the medication.
    • Sleep and appetite generally improve first.
    • Positive changes in mood, energy, and negative thinking usually take longer.
4. Most people require at least nine months of treatment with antidepressants. Some require longer.
5. Discuss problems or side effects with your doctor as soon as possible. DO NOT wait until your next appointment.
6. DO NOT stop the medication before talking to your doctor, even if you feel better.

Depression is a serious illness that is usually responsive to treatment. Working with your health care providers, you can feel better.